39 lines
2.3 KiB
Plaintext
39 lines
2.3 KiB
Plaintext
<%@ Control Language="C#" AutoEventWireup="true" CodeBehind="mod_home.ascx.cs" Inherits="WebLCP.WUC.mod_home" %>
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<div class="card">
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<div class="card-header bg-dark text-light">
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<div class="row">
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<div class="col-9">
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<h2>The dark side of APOE:</h2>
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<h4>unravelling amyloid-independent effects in Alzheimer’s Diesease (AD)</h4>
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</div>
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<div class="col-3 text-right p-0">
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<img src="../Images/brain.png" class="img-fluid" width="128" />
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</div>
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</div>
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</div>
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<div class="card-body">
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<div class="titoloViola">
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</div>
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<br />
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<p>
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This project will be carried out by the Laboratory of Alzheimer’s Neuroimaging and Epidemiolog (LANE) and the Unit of Statistics of the IRCCS Fatebenefratelli in Brescia, Italy. The two units have a well-established expertise in AD biomarkers scientific investigation and analyses.
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The project aims at detecting the presence of any cut-offs in AD biomarkers distribution that allows to classify subject/patients in terms of prognostic evaluation.
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</p>
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This tool:
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<ul>
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<li>provides finite Gaussian mixture model output: i.e. identify sub-populations and cut-off values for each biomarker distribution taking or not into account the genetic and demographic variables effects;</li>
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<li>handles several jobs (i.e. input data file) simultaneously for each user (the jobs are processed in batch and an email is sent to the user when the execution of jobs is completed);</li>
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<li>produces two different output file for each job (Results file with model estimation text output; Results plot with output plots -densities and scatterplots- of unadjusted and adjusted cut-offs);</li>
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<li>allows to display and export simultaneously selected output plot of different jobs.</li>
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</ul>
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<hr />
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<h4>Hot to use this tool?</h4>
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Please proceed to <asp:HyperLink runat="server" NavigateUrl="~/RegisterUser" class="btn btn-sm btn-success">Login Page »</asp:HyperLink>
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</div>
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<div class="card-footer">
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<b>How to cite:</b>
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<div>Marizzoni M., Ferrari C., et al. CSF cut-offs for MCI due to AD depend on APOEε4 carrier status Neurobiology of Aging, 2019 <a target="_blank" href="https://doi.org/10.1016/j.neurobiolaging.2019.12.019">https://doi.org/10.1016/j.neurobiolaging.2019.12.019</a></div>
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</div>
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</div>
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